Preclinical Drug Discovery Course
Venue: KAIMRC
Day: 13 September 2022
Time: 9 am. 12 p.m
Introduction
KAIMRC is actively involved in drug discovery and its successes in this field are demonstrated by publications, patents and clinical trials. In order to further support this effort, KAIMRC has state-of-the-art infrastructure which are readily accessible by its researchers.
The aim of this workshop is to give an overview of the drug discovery and development process. There will a particular focus on pre-clinical drug discovery, namely drug target identification and validation, development of assays, screening, identification of chemical starting points for drug discovery and their optimization so they are suitable for evaluation in the clinic.
Experts in the field will describe the above processes and participate in a Q&A session to answer any specific questions.
Course Objectives
- Train a cadre of interdisciplinary scientists in the principles of drug discovery.
- Describe the biological processes in drug target identification and validation, assay development and screening compound libraries.
- Illustrate how the chemical matter identified from the screening activities are optimized using experimental compound synthesis, computational methods and ADMET prior to clinic evaluation.
- Demonstrate that drug discovery is a team effort that requires collaboration of a multi-disciplinary team including experts in basic medical research, medicinal chemistry, intellectual property, regulatory affairs, clinical trial management and the commercial management of the life cycle of drugs.
- Provide a platform to exchange ideas, knowledge and resources to accelerate drug discovery at KAIMRC.
Who should attend?
This workshop is designed for researchers, clinicians and managers who wish to learn about the processes, challenges and rewards of working in drug discovery.
About the Speakers:
Cell Culture and Cell Based Assays Course
Date: September, 13-14, 2021
Time: 9 am. 12 p.m.
Introduction:
Mammalian cell culture is an integral tool in many workflows of biological studies. This course is designed to provide key cell culture techniques and best practice for maintaining healthy cell lines and obtaining the most accurate and reproducible results in downstream applications. This training program will focus on how cell culture is used for in vitro assays. It will help attendees understand the uses of an in vitro testing with eukaryotic cell based systems and the parameters to be considered in the development and the optimization of a cell based assay.
Course objectives:
- Good cell culture practice including safety procedures, exposure to facilities’ equipment, Reagents preparation, storage and handling, principles of aseptic techniques i.e. how to use Class II safety cabinets
- Media preparation, cell line maintenance, passaging, freezing and recovery.
- Manipulation of established cell lines under various experimental conditions. For example paraptosis induction and spheroids formation.
- Transient transfection of mammalian cells and imaging under fluorescence microscopy.
- Performing cell-based techniques such as cell viability, proliferation and cell death analysis.
Who should attend?
This course is intended for graduate students, post-graduate students and health science professionals who are interested in Cell culture and cell based assays.
Instructor:
High Content Imaging (HCI) in Drug discovery and development 3 hours
Date: 13 September 2022
Time: 9 am. 12 p.m.
- Introduction to HCI
- Assay development in phenotypic drug discovery
- Data acquisition
- User guided large data sets analysis
- Deep learning in HCI
Instructor
Phage display and Oncolytic Viruses: Role of AI IN THERAPEUTIC DISCOVERY
Date: 13 September 2022
Learning Objectives:
- Discuss Phage display: A powerful monoclonal antibodies discovery platform
- Discuss Oncolytic Viruses and challenges in research
- Discuss Artificial intelligence software’s in Therapeutic Discovery
Brief Description of the course:
Development, Current Status, and Future Directions of Phage display monoclonal antibodies, Oncolytic viruses, and the role of AI in helping direction of their therapeutic discovery
Who should attend
- Graduate Students
- Academicians
- Researchers interested in Health and life sciences
Instructor:
RNA- Based technologies: Development, Current Status, and Future Directions
Date: 13 September 2022
Time: 9 am. 12 p.m.
Learning Objectives:
- Discuss mRNA Based Therapeutics and Vaccines development for COVID-19
- Discuss mRNA-based cancer vaccine innovation and development
- Discuss siRNA and micro-RNA Based Therapeutics development for cancer and other diseases
Brief Description of the course:
This course will be discussing RNA- Based technologies: Development, Current Status, and Future Directions
Who should attend
- Graduate Students
- Academicians
- Researchers interested in Health and life sciences
Instructor: